The growth cone above was optically recorded, then fixed and processed for whole-mount electron microscopy to correlate cytoskeletal structure with motile history and function.
Arrows indicate filopodia;
arrowheads indicate actin bundles.
by Ken Balazovich
Polinsky, M., K. Balazovich and K.W. Tosney (2000). Identification of an invariant response: Contact with Schwann cells induces veil extension in growth cones. J. Neurosci. 20: 1044-1055.
Steketee, M., K. Balazovich and K.W. Tosney (2001) Filopodial Initiation and a Novel Filament-organizing Center, the Focal Ring. Mol. Biol. Cell 2001 12: p. 2378-2395
Tosney, K. W. , A. Wagnitz, D. Dehnbostel, and K. J. Balazovich (2006). Evidence that growth cones exert mechanical force as they exit the spinal cord. in press with revision